Current practice of neoadjuvant therapy and total mesorectal excision (TME) in rectal cancer bears the weakness in systemic disease control and long-term functional outcomes.With increasing concerns of the balance between cure and quality of life, new strategies are developed to better oncological 3 Piece Queen Poster Bed outcomes at least cost of function damage.Attractive options to adjust neoadjuvant modality include escalation of radiotherapy, intensification of chemotherapy, and chemoradiotherapy with consolidation or full-course chemotherapy.Subsequently, organ-preserving strategies have gained the popularity.
Surgical or nonsurgical approaches that spare the rectum are Left Rear Foot used as possible alternatives for radical surgery, though high-quality TME remains the last resort to offer reliable local disease control.This review discusses new strategies of neoadjuvant therapy and subsequent management, with a specific focus on the balance between oncological and functional outcomes.